Karneval. Chapter 74

Another re-translation! I absolutely loved this part, but the translation I’ve seen on the web is kind of.. off.

utter-fucktard:

If a 7 year old realises gender stereotyping is wrong and you don’t, something is very wrong with you.

utter-fucktard:

If a 7 year old realises gender stereotyping is wrong and you don’t, something is very wrong with you.

(via shychemist)

neurosciencestuff:

Physicists push new Parkinson’s treatment toward clinical trials
The most effective way to tackle debilitating diseases is to punch them at the start and keep them from growing.
Research at Michigan State University, published in the Journal of Biological Chemistry, shows that a small “molecular tweezer” keeps proteins from clumping, or aggregating, the first step of neurological disorders such as Parkinson’s disease, Alzheimer’s disease and Huntington’s disease.
The results are pushing the promising molecule toward clinical trials and actually becoming a new drug, said Lisa Lapidus, MSU associate professor of physics and astronomy and co-author of the paper.
“By the time patients show symptoms and go to a doctor, aggregation already has a stronghold in their brains,” she said. “In the lab, however, we can see the first steps, at the very place where the drugs could be the most effective. This could be a strong model for fighting Parkinson’s and other diseases that involve neurotoxic aggregation.”
Lapidus’ lab uses lasers to study the speed of protein reconfiguration before aggregation, a technique Lapidus pioneered. Proteins are chains of amino acids that do most of the work in cells. Scientists understand protein structure, but they don’t know how they are built – a process known as folding.
Lapidus’ lab has shed light on the process by correlating the speed at which an unfolded protein changes shape, or reconfigures, with its tendency to clump or bind with other proteins. If reconfiguration is much faster or slower than the speed at which proteins bump into each other, aggregation is slow, but if reconfiguration is the same speed, aggregation is fast.
Srabasti Acharya, lead author and doctoral candidate in Lapidus’ lab, tested the molecule, CLR01, which was patented jointly by researchers at the University of Duisburg-Essen (Germany) and UCLA. CLR01 binds to the protein and prevents aggregation by speeding up reconfiguration. It’s like a claw that attaches to the amino acid lysine, which is part of the protein.
This work was preceded by Lapidus’ research involving the spice curcumin. While the spice molecules put the researchers on a solid path, the molecules weren’t viable drug candidates because they cannot cross the blood-brain barrier, or BBB, the filter that controls what chemicals reach the brain.
It’s the BBB, in fact, that disproves the notion that people should simply eat more spicy food to stave off Parkinson’s disease.
Spicy misconceptions notwithstanding, CLR01 mimics curcumin molecules’ ability to prevent aggregation. But unlike the spice, CLR01 can crossover the BBB and treat its targeted site. Not only do they go to the right place, but CLR01 molecules also work even better because they speed up reconfiguration even more than curcumin. Additionally Acharya showed that CLR01 slows the first step of aggregation, and the results from the study map out a clear road map for moving the drug to clinical trials.
Hearing about a nontraditional physics lab that was advancing medicine is what brought Acharya to work with Lapidus.
“I knew I wanted to study physics when I came to MSU, but when I heard Dr. Lapidus’ presentation during orientation, I knew this is what I wanted to do,” Acharya said. “We are using physics to better understand biology to help cure actual diseases.”
To help move the research to the next phase, Gal Bitan, co-author and professor at UCLA, is using crowdsourcing to raise funds for the clinical trials. Log on to the indiegogo.com website for more information.

neurosciencestuff:

Physicists push new Parkinson’s treatment toward clinical trials

The most effective way to tackle debilitating diseases is to punch them at the start and keep them from growing.

Research at Michigan State University, published in the Journal of Biological Chemistry, shows that a small “molecular tweezer” keeps proteins from clumping, or aggregating, the first step of neurological disorders such as Parkinson’s disease, Alzheimer’s disease and Huntington’s disease.

The results are pushing the promising molecule toward clinical trials and actually becoming a new drug, said Lisa Lapidus, MSU associate professor of physics and astronomy and co-author of the paper.

“By the time patients show symptoms and go to a doctor, aggregation already has a stronghold in their brains,” she said. “In the lab, however, we can see the first steps, at the very place where the drugs could be the most effective. This could be a strong model for fighting Parkinson’s and other diseases that involve neurotoxic aggregation.”

Lapidus’ lab uses lasers to study the speed of protein reconfiguration before aggregation, a technique Lapidus pioneered. Proteins are chains of amino acids that do most of the work in cells. Scientists understand protein structure, but they don’t know how they are built – a process known as folding.

Lapidus’ lab has shed light on the process by correlating the speed at which an unfolded protein changes shape, or reconfigures, with its tendency to clump or bind with other proteins. If reconfiguration is much faster or slower than the speed at which proteins bump into each other, aggregation is slow, but if reconfiguration is the same speed, aggregation is fast.

Srabasti Acharya, lead author and doctoral candidate in Lapidus’ lab, tested the molecule, CLR01, which was patented jointly by researchers at the University of Duisburg-Essen (Germany) and UCLA. CLR01 binds to the protein and prevents aggregation by speeding up reconfiguration. It’s like a claw that attaches to the amino acid lysine, which is part of the protein.

This work was preceded by Lapidus’ research involving the spice curcumin. While the spice molecules put the researchers on a solid path, the molecules weren’t viable drug candidates because they cannot cross the blood-brain barrier, or BBB, the filter that controls what chemicals reach the brain.

It’s the BBB, in fact, that disproves the notion that people should simply eat more spicy food to stave off Parkinson’s disease.

Spicy misconceptions notwithstanding, CLR01 mimics curcumin molecules’ ability to prevent aggregation. But unlike the spice, CLR01 can crossover the BBB and treat its targeted site. Not only do they go to the right place, but CLR01 molecules also work even better because they speed up reconfiguration even more than curcumin. Additionally Acharya showed that CLR01 slows the first step of aggregation, and the results from the study map out a clear road map for moving the drug to clinical trials.

Hearing about a nontraditional physics lab that was advancing medicine is what brought Acharya to work with Lapidus.

“I knew I wanted to study physics when I came to MSU, but when I heard Dr. Lapidus’ presentation during orientation, I knew this is what I wanted to do,” Acharya said. “We are using physics to better understand biology to help cure actual diseases.”

To help move the research to the next phase, Gal Bitan, co-author and professor at UCLA, is using crowdsourcing to raise funds for the clinical trials. Log on to the indiegogo.com website for more information.

milkykiss:

went to eat ice cream waffles @ 빵굼터(korean bakery/cafe) right after school w/ my lovely minjung

milkykiss:

went to eat ice cream waffles @ 빵굼터(korean bakery/cafe) right after school w/ my lovely minjung

(via fukawah)

jedavu:

ILLUMINATED CODE FROM SPACE

"Macrocosm and microcosm is an ancient Greek Neo-Platonic schema of seeing the same patterns reproduced in all levels of the cosmos, from the largest scale (macrocosm or universe-level) all the way down to the smallest scale (microcosm or sub-sub-atomic or even metaphysical-level). In the system the midpoint is Man, who summarizes thecosmos."

by aari Tesla

(via bullshit-bullsharks)

cognitivedefusion:

Standard Deviation

scienceofeds:

Please read this if you are not familiar with the concept of standard deviation. It is important for better understanding a lot of the content that I’ve blogged about and include on this Tumblr. Yes I can “dumb it down” enough not to use standard deviation but I’d prefer to think that the concept is actually not as hard as people make it out to be and it is better to educate than to assume everyone is just too dumb.

This is an excerpt from the site:

Why is this useful? Here’s an example: If you are comparing test scores for different schools, the standard deviation will tell you how diverse the test scores are for each school.

Let’s say Springfield Elementary has a higher mean test score than Shelbyville Elementary. Your first reaction might be to say that the kids at Springfield are smarter.

But a bigger standard deviation for one school tells you that there are relatively more kids at that school scoring toward one extreme or the other. By asking a few follow-up questions you might find that, say, Springfield’s mean was skewed up because the school district sends all of the gifted education kids to Springfield. Or that Shelbyville’s scores were dragged down because students who recently have been “mainstreamed” from special education classes have all been sent to Shelbyville.

In this way, looking at the standard deviation can help point you in the right direction when asking why information is the way it is.

The Wikipedia Page might be even better actually.

Standard deviation is a number used to tell how measurements for a group are spread out from the average (mean), or expected value. A low standard deviation means that most of the numbers are very close to the average. A high standard deviation means that the numbers are spread out.[1][2]

Standard deviation is also used to measure how close a reported number is to being exactly right. For example, the standard deviation is used to find margin of error in opinion poll numbers.

It’s really tough, if not impossible, to do science without a basic grasp of these concepts. I understand a lot of people dislike statistics, but it’s kind of essential if you want to be awesome in any field that requires even a hint of science.

thegestianpoet:

here’s the thing:

  • respect sex workers, but
  • do not defend the porn industry 

(via thebaptizedagnostic)

Animation/Drawing Reference

fuckyeahcharacterdevelopment:

Reference! Reference! is a free database that collects different video clips, with categories ranging from facial expressions, to styles of fighting, and animals in motion. 

image 

You can play and pause the videos, and move through them frame-by-frame easily.

I’m freaking out, man. 

-Evvy

(via ophexis)

There was a study done where they got a man to harass a woman in the park
and then they did it the other way around.
Several stopped the man but they let the woman slap and scream
and yank his hair.
They asked a professional who concluded that compared to men,
women aren’t seen as enough to be a threat.

My friend’s principal from three years ago
took his kids and ran
because he kept showing up to work
with bruises put there weekly by his loving wife
and everyone told him to take it like a man.

Last week I listened as a guy laughed off the idea
that a woman could violate him
and I thought of an interview on a news show
where they showed a boy who flinched inwards
every time a girl touched him
because of the exact reason the guy laughed off.

When compared to men,
Women aren’t seen as a threat
so men feel free to take whatever they like.

Women aren’t seen as a threat
so no one takes men seriously
when a woman
breaks them open.

'When a Girl Slaps a Guy on a Sitcom It's Hilarious: Why Guys Need Feminism,' theappleppielifestyle. (via theappleppielifestyle)

Can I just say that it’s so nice to see something about women abusing men that doesn’t try to say feminism is the root of all evil, and in fact realizes the sexism against women is part of why this shit happens?

(via faeriviera)

(via forumgamer)

Male privilege is “I have a boyfriend” being the only thing that can actually stop someone from hitting on you because they respect another man more than they respect your rejection/lack of interest.

The Sociological Cinema

There was actually research that was done that found that women who used an “I have a boyfriend/husband” excuse to reject unwanted sexual attention and harassment by their bosses were more likely to be left alone than those who used any other excuse (including “I’m not interested”)

Because men respect another man’s property (and that’s how they see us) than a woman’s autonomy.

(via stanhowse)

(via mrdespondency)

facebooksexism:

TW: Suicide
Dude says he’s gonna kill himself if he doesn’t get a nude and everyone is concerned with him being “Teacher-zoned”. If that doesn’t show how entitled these people are I don’t know what is

facebooksexism:

TW: Suicide

Dude says he’s gonna kill himself if he doesn’t get a nude and everyone is concerned with him being “Teacher-zoned”. If that doesn’t show how entitled these people are I don’t know what is

Anonymous asked: Sometimes I get really scared that I'll end up alone because nobody wants to waste their life with someone who is "just a friend". I don't even have any close friends right now because most of my friends are panromantic and I'd feel bad if anyone got a crush on me

aroproblems:

this was my fear for a while, even before realizing i was aromantic. my friends are hertoramtic so i feel your distress. then when i realized i was aromantic i got even more concerned with how people would react after i tell them i want nothing of a romantic relationship. i think all that we, all that you can do is not feel bad, because you can’t help what you feel and who you are. you just have to just say “hay look i’m not into you like that, your crush on me is making me kind of uncomfortable, but we can be close, or more than this just not in a romantic way..”

you can’t be afraid for being alone, you have to understand there are people out there just like you, more that probably don’t know that they are really aromantics. so give each a chance. and if they don’t want to take the time to know you, befriend you and maybe become your zucchini, then that is their lost. move on. remember there are always some one out there for you. don’t get discourage. 

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